520.1921 Prochlorperazine, isopropamide with neomycin sustained-release capsules.

Specifications: Each capsule contains either Capsule No. 1 which contains 3.33 milligrams of prochlorperazine (as the dimaleate), 1.67 milligrams of isopropamide (as the iodide), and 25 milligrams of neomycin base (as the sulfate) or Capsule No. 3 which contains 10 milligrams of prochlorperazine (as the dimaleate), 5 milligrams of isopropamide (as the iodide), and 75 milligrams of neomycin base (as the sulfate).

Conditions of use:

Dogs

Amount: 10 to 20 pounds body weight- 1 #1 capsule, orally twice daily to dogs. 20 to 30 pounds body weight- 2 #1 capsules, orally twice daily to dogs. Over 30 pounds body weight- 3 #1 capsules or 1 #3 capsules, orally twice daily to dogs. Over 60 pounds- 2 #3 capsules, orally twice daily to dogs.

Indications: For treatment of dogs in which infectious bacterial gastroenteritis is associated with emotional stress.

Limitations: Do not continue medication longer than 5 days. Overdosage or prolonged administration may produce nephrotoxicity as manifested by albuminuria, presence of granular casts and depressed urinary output. If it is desirable to administer a vasoconstrictor, norepinephrine is the drug of choice. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Tolerances are established for residues of parent neomycin in uncooked edible tissues as follows:

a. In cattle, swine, sheep, and goats: 7.2 parts per million in kidney (target tissue) and fat, 3.6 ppm in liver, and 1.2 ppm in muscle.

b. In turkeys: 7.2 ppm in skin with adhering fat, 3.6 parts per million in liver, and 1.2 ppm in muscle.

c. In milk: 0.15 part per million.